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Published 2022 Nov 3

Thus, the researchers concluded that this interaction may potentially shield islets against the detrimental effects of proinflammatory cytokines, which might be released by activated macrophages or as a result of the transplantation procedure itself

"For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications." Although the biological mechanism remains unclear, Gloyn believes the answer is likely complex and influenced by multiple factors

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